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Canadian STI Guidelines

Pages 136-137: Treatment - Youth and adults

Urethral, Endocervical, Rectal Infection
(except in pregnant women and nursing mothers)

Pelvic inflammatory disease, see page 80
Epididymitis, see page 100

Preferred:

  • Azithromycin 1 g orally in a single dose(a)

Alternative:

  • Doxycycline 100 mg orally bid for 7 days

Other alternatives:

  • Ofloxacin 300 mg bid for 7 days

OR

  • Erythromycin 2 g/day orally in divided doses for 7 days(b)

OR

  • Erythromycin 1 g/day orally in divided doses for 14 days(b)

Notes:
(a) If vomiting occurs more than one hour post administration, a repeat dose is not required.
(b) Erythromycin dosages refer to the use of erythromycin base. Equivalent dosages of other formulations (EXCEPT the estolate which is contraindicated in pregnancy) may be substituted. If erythromycin has been used for treatment, repeat testing after completion of therapy is advisable.

 

Urethral, Endocervical, Rectal Infection in Pregnant Women and Nursing Mothers

Preferred:

  • Amoxicillin 500 mg orally tid for 7 days

OR

  • Erythromycin 2 g/day orally in divided doses for 7 days(a)

Alternative:

  • Azithromycin 1 g orally in a single dose(b)

Notes:
(a) Erythromycin dosage refers to the use of erythromycin base. Equivalent dosages of other formulations (EXCEPT the estolate which is contraindicated in pregnancy) may be substituted. If erythromycin or amoxicillin has been used for treatment, repeat testing after completion of therapy is advisable.
(b) To date, there are limited data collected on azithromycin in pregnancy but it is considered to be safe in this context by many experts.