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Canadian Immunization Guide

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Part 1
Key Immunization Information

Contents of Immunizing Agents Available for Use in Canada

The following tables provide a comprehensive list of contents of immunizing agents available in Canada. Table 1 lists contents of active vaccines and Table 2 lists contents of passive immunizing agents. Vaccine providers should consult the product label, product leaflet, or product monograph for current product information. Manufacturers provide evidence of vaccine safety and efficacy and receive authorization for the immunizing agent only when it is used in accordance with the product monograph available through Health Canada's Drug Product Database.

Table 1: Types and Contents of Vaccines Available for Use in Canada

  • For current, complete prescribing information vaccine providers should consult the product leaflet or information contained within the product monographs available through Health Canada's Drug Product Database.
  • Any component in a vaccine may be a potential allergen. This table identifies most common allergens; adjuvants and preservatives may be potential allergens, but this is extremely rare.
  • Information about the vaccine manufacturer/distributor is available in vaccine specific chapters in Part 4.
Table 1: Types and Contents of Vaccines Available for Use in Canada
Brand name Route Vaccine type
(live; inactivated)
Immunogen Adjuvant Preservative Potential allergens Other materials Abbreviation
  • Empty boxes indicate that there are no materials of relevance in the product.

Footnotes:

Table 1 - Footnote 1
Multi-dose presentation only.
Table 1 - Footnote 2
Smallpox vaccine (dried) is not available for general use.
Table 3 - Footnote 3
Smallpox vaccine (frozen liquid) is not a Health Canada authorized product but will be released under Health Canada's Special Access Program if required.
Act-HIB® IM Inactivated Hib     Tetanus toxoid carrier protein Sodium chloride
Sucrose
Trometamol
Hib
ADACEL® IM Inactivated T
d
ap
Alum PE   Formaldehyde
Glutaraldehyde
Tdap
ADACEL®-POLIO IM Inactivated T
d
ap
IPV
Alum PE Neomycin
Polymyxin B
Streptomycin
Bovine serum albumin
Formaldehyde
Glutaraldehyde
Polysorbate 80
Water for injection
Tdap-IPV
AGRIFLU® IM Inactivated Inf     Egg protein
Kanamycin
Neomycin
Barium
Calcium chloride
Cetyltrimethylammonium bromide
Citrates
Disodium phosphate dihydrate
Formaldehyde
Magnesium chloride
Polysorbate 80
Potassium chloride
Potassium dihydrogen phosphate
Sodium chloride
Water for injection
TIV
AVAXIM® IM Inactivated HA Alum PE
CH2O
Neomycin Medium 199 Hanks
Polysorbate 80
Water for injection
HA
AVAXIM® Pediatric
BEXSERO® IM Inactivated Men B Alum   Latex in tip cap of syringe Sodium chloride,
Histidine,
Sucrose,
Water for injections
Latex
4CMenB
BOOSTRIX® IM Inactivated T
d
ap
Alum     Formaldehyde
Glycine
Polysorbate 80
Sodium chloride
Water for injection
Tdap
BOOSTRIX®-POLIO IM Inactivated T
d
ap
IPV
Alum   Neomycin
Polymyxin B
Formaldehyde
Medium 199
Sodium chloride
Water for injection
Tdap-IPV
CERVARIX® IM Inactivated HPV AS04   Latex in plunger stopper of pre-filled syringe Hydrated sodium chloride
Sodium dihydrogen phosphate dihydrate
Water for injection
HPV2
DUKORAL® Oral Inactivated Chol
Ecol
      Citric acid
Disodium hydrogen phosphate
Raspberry flavor
Saccharin sodium
Sodium carbonate
Sodium citrate
Sodium chloride
Sodium dihydrogen phosphate
Sodium hydrogen carbonate
Water for injection
Chol-Ecol-O
ENGERIX®-B IM Inactivated HB Alum TmFootnote 1
PEFootnote 1
Yeast protein
ThimerosalFootnote 1
Disodium phosphate dihydrate
Polysorbate 20
Sodium chloride
Sodium dihydrogen phosphate dihydrate
HB
ENGERIX®-B
Pediatric dose
FLUAD® IM Inactivated Inf MF59   Egg protein
Kanamycin
Neomycin
Barium
Calcium chloride dihydrate
Cetyltrimethylammonium bromide
Disodium phosphate dihydrate
Formaldehyde
Magnesium chloride hexahydrate
Polysorbate 80
Potassium chloride
Potassium dihydrogen phosphate
Sodium chloride
Water for injection
TIV
Flulaval™ Tetra IM Inactivated Inf   Tm Egg proteins
Thimerosal
α-tocopheryl hydrogen succinate
Ethanol
Formaldehyde
Phosphate buffered saline
Polysorbate 80
Sodium deoxycholate
Sucrose
QIV
FLUMIST® IN Live Inf     Arginine
Egg protein
Gelatin
Gentamicin
Dibasic potassium phosphate
Monosodium glutamate
Monobasic potassium phosphate
Sucrose
LAIV
FLUVIRAL® IM Inactivated Inf   Tm Egg protein
Thimerosal
Disodium hydrogen phosphate heptahydrate
Formaldehyde
Potassium chloride
Potassium dihydrogen phosphate
Sodium chloride
Sodium deoxycholate
Sucrose
Water for injection
TIV
FLUZONE® IM Inactivated Inf   TmFootnote 1 Egg protein
Gelatin
Neomycin
ThimerosalFootnote 1
Formaldehyde
Gelatin
Sucrose
Triton® X-100
TIV
FLUZONE®
Quadrivalent
IM Inactivated Inf   TmFootnote 1 Egg protein
ThimerosalFootnote 1
Formaldehyde
Triton® X-100
Sodium phosphate-buffered isotonic sodium chloride solution
QIV
GARDASIL® IM Inactivated HPV Alum   Yeast protein L-histidine
Polysorbate 80
Sodium borate
Sodium chloride
Water for injection
HPV4
HAVRIX® IM Inactivated HA Alum   Neomycin Amino acids
Disodium phosphate
Formaldehyde
Monopotassium phosphate
Polysorbate 20
Potassium chloride
Sodium chloride
Water for injection
HA
HAVRIX® 720 JUNIOR
HIBERIX® IM Inactivated Hib     Tetanus toxoid carrier protein Lactose
Sodium chloride
Hib
IMOVAX® Polio SC Inactivated IPV   PE Neomycin
Polymyxin B
Streptomycin
Bovine serum
Formaldehyde
Medium 199 Hanks
Polysorbate 80
IPV
IMOVAX® Rabies IM Inactivated Rab     Neomycin
Phenol red
Human albumin
Water for injection
HDCV
INFANRIX hexa® IM Inactivated D
T
aP
HB
IPV
Hib
Alum   Latex in plunger stopper of pre-filled syringe
Neomycin
Polymyxin B
Tetanus toxoid carrier protein
Yeast protein
Disodium phosphate
Formaldehyde
Glycine
Lactose
M199
Monopotassium phosphate
Polysorbate 20 and 80
Potassium chloride
Sodium chloride
Water for injection
DTaP-HB-IPV-Hib
INFANRIX®-IPV IM Inactivated D
T
aP
IPV
    Neomycin
Polymixin
Sodium chloride
Aluminum Salts
M 199
Water for injections
DTaP-IPV
INFANRIX®-IPV/Hib IM Inactivated D
T
aP
IPV
Hib
Alum   Neomycin
Polymixin
Tetanus toxoid carrier protein
Lactose
Sodium chloride
M199
Water for injection
Residual formaldehyde
Polysorbate 80
Potassium chloride
Disodium phosphate, Monopotassium phosphate
Glycine
DTaP-IPV-Hib
INFLUVAC® IM Inactivated Inf     Chick protein
Egg protein
Gentamicin
Calcium chloride dihydrate
Cetyltrimethylammonium bromide
Disodium phosphate dihydrate
Formaldehyde
Magnesium chloride hexahydrate
Polysorbate 80
Potassium chloride
Potassium dihydrogen phosphate
Sodium chloride
Water for injection
TIV
IXIARO® IM Inactivated JE Alum     Disodium hydrogen phosphate
Potassium dihydrogen phosphate
Sodium chloride
Water for injection
JE
Menactra® IM Inactivated Men     Diphtheria toxoid
carrier protein
Sodium chloride
Sodium phosphate dibasic (anhydrous)
Sodium phosphate monobasic
Water for injection
Men-C-ACYW-DT
Menjugate® IM Inactivated Men Alum   Latex in tip cap of syringe
Diphtheria CRM197
toxoid carrier protein
Disodium phosphate heptahydrate
Mannitol
Sodium chloride
Sodium dihydrogen phosphate monohydrate
Water for injection
Men-C-C-CRM
MENOMUNE® A/C/Y/W-135 SC Inactivated Men   TmFootnote 1 Latex in stopper Lactose
Sodium chloride
Men-P-ACYW-135
MenveoTM IM Inactivated Men     Diphtheria CRM197
toxoid carrier protein
Disodium hydrogen
phosphate bihydrate
Potassium dihydrogen phosphate
Sodium chloride
Sodium dihydrogen phosphate monohydrate
Sucrose
Water for injection
Men-C-ACYW-CRM
M-M-R® II SC Live Meas
Mumps
R
    Neomycin
Phenol red
Porcine gelatin
Residual components of chick embryo cell cultures
Fetal bovine serum
Medium 199 with Hank's salts
Minimum essential medium (Eagle)
Monosodium L-glutamate monohydrate
Potassium phosphate dibasic (anhydrous)
Potassium phosphate monobasic
Recombinant human albumin
Sodium bicarbonate
Sodium phosphate dibasic (anhydrous)
Sodium phosphate monobasic
Sorbitol
Sucrose
Water for injection
MMR
NeisVac-C® IM Inactivated Men Alum   Tetanus toxoid carrier protein Sodium chloride Men-C-C-TT
NIMENRIX® IM Inactivated Men     Tetanus toxoid carrier protein Sucrose
Trometamol
Sodium chloride
Water for injection
Men-C-ACYW-TT
PEDIACEL® IM Inactivated DTaP
-IPV
Hib
Alum PE Neomycin
Polymyxin B
Streptomycin
Tetanus toxoid carrier protein
Bovine serum albumin
Formaldehyde
Glutaraldehyde
Polysorbate 80
DTaP-IPV-Hib
PNEUMOVAX® 23 SC/IM Inactivated Pneu   P   Sodium chloride
Water for injection
Pneu-P-23
Prevnar® 13 IM Inactivated Pneu Alum   Diphtheria CRM197
toxoid carrier protein
Polysorbate 80
Sodium chloride
Succinic acid
Water for injection
Pneu-C-13
PRIORIX® SC/IM Live Meas
Mumps
R
    Egg protein
Neomycin
Amino acids
Lactose
Mannitol
Sorbitol
Water for injection
MMR
PRIORIX-TETRA® SC/IM Live Meas
Mumps
R
Var
    Egg protein
Neomycin
Amino Acids
Lactose
Mannitol
Sorbitol
Water for injection
MMRV
PROQUAD™ SC Live Meas
Mumps
R
Var
    Gelatin
Neomycin
Sucrose
Urea
Sodium chloride
Sorbitol
Monosodium L-glutamate
Sodium phosphate
Human albumin
MMRV
QUADRACEL® IM Inactivated DTaP
IPV
Alum PE Neomycin
Polymyxin B
Bovine serum albumin
Formaldehyde
Glutaraldehyde
Polysorbate 80
DTaP-IPV
RabAvert® IM Inactivated Rab     Amphotericin B
Chick protein
Chlortetracycline
Neomycin
Polygeline (gelatin)
Egg protein
Human serum albumin PCECV
RECOMBIVAX HB® IM Inactivated HB Alum   Latex in vial stopper
Yeast protein
Formaldehyde
Sodium borate
Sodium chloride
Water for injection
HB
ROTARIX® Oral Live Rot       Disodium adipate
DNA fragments from porcine circovirus 1
Dulbecco's Modified Eagle Medium
Sterile water
Sucrose
Rot-1
RotaTeq® Oral Live Rot       DNA fragments from porcine circoviruses 1 and 2
Fetal bovine serum
Polysorbate 80
Residual protein from cell culture
Sodium citrate dihydrate
Sodium hydroxide
Sodium phosphate monobasic monohydrate
Sucrose
Rot-5
Smallpox (dried)Footnote 2 ID Live Vaccinia     Latex in stopper of vaccine vial
Neomycin
Streptomycin
Bovine tissue (trace)
Glycerol
McIlvaine buffer
Phenol
Sma
Smallpox (frozen)Footnote 3               Sma
SYNFLORIX® IM Inactivated Pneu Alum   Latex in syringe components
Diphtheria toxoid carrier protein
Tetanus toxoid carrier protein
Non-typeable Haemophilus influenzae protein D carrier protein
Sodium chloride
Water for injection
Pneu-C-10
Td ADSORBED IM Inactivated Td Alum PE   Formaldehyde
Sodium chloride
Water for injection
Td
Td POLIO ADSORBED IM Inactivated Td
IPV
Alum PE Neomycin
Polymyxin B
Bovine serum albumin
Formaldehyde
Polysorbate 80
Td-IPV
TWINRIX®
IM Inactivated HA
HB
Alum  

Neomycin
Yeast protein

Amino acids
Formaldehyde
Polysorbate 20
Sodium chloride
Water for injection
HAHB
TWINRIX® Junior
TYPHERIX® IM Inactivated Typh   P   Disodium phosphate dihydrate
Sodium chloride
Sodium phosphate dihydrate
Water for injection
Typh-I
TYPHIM Vi® IM Inactivated Typh   P   Isotonic buffer solution Typh-1
VAQTA® IM Inactivated HA Alum   Latex in vial stopper
Neomycin
Bovine albumin
DNA
Formaldehyde
Residual protein from cell culture
Sodium borate
Sodium chloride
Water for injection
HA
VARILRIX® SC Live Var     Neomycin Amino acids
Human albumin
Lactose
Polyalcohols
Water for injection
Var
VARIVAX® III SC Live Var     Neomycin
Porcine gelatin
Fetal bovine serum
Monosodium L-glutamate
Potassium chloride
Potassium phosphate monobasic
Residual protein from cell culture
Sodium chloride
Sodium phosphate dibasic
Sucrose
Urea
Water for injection
Var
VAXIGRIP® IM Inactivated Inf   TmFootnote 1 Egg protein
Neomycin
ThimerosalFootnote 1
Disodium phosphate dihydrate
Formaldehyde
Potassium chloride
Potassium dihydrogen phosphate
Sodium chloride
Sucrose
Triton® X-100
TIV
ViVAXIM® IM Inactivated Typh++
(HA)
Alum PE CH2O Neomycin Disodium phosphate dihydrate
Medium 199 Hanks
Polysorbate 80
Sodium chloride
Sodium dihydrogen phosphate dihydrate
Water for injection
HA-Typh-I
Vivotif® Oral Live Typh     Gelatin Amino acid mixture
Ascorbic acid
Dibutyl phthalate
Diethyl phthalate
Erythrosine FD+C red 3
Ethylene glycol
Hydroxypropylcellulose-phthalate
Lactose
Magnesium stearate
Red iron oxide
Sucrose
Titanium dioxide
Yellow iron oxide
Typh-O
YF-VAX® SC Live YF     Chick protein
Egg protein
Gelatin
Latex in stopper of diluent vial
Sodium chloride
Sorbitol
YF
ZOSTAVAX® SC Live Zos     Neomycin
Porcine gelatin
Bovine calf serum
Monosodium L-glutamate monohydrate
Potassium chloride
Potassium phosphate monobasic
Residual protein from cell culture
Sodium chloride
Sucrose
Sodium phosphate dibasic
Water for injection
HZV

Abbreviations

Route-

ID
intradermal
IM
intramuscular
IN
intranasal
SC
subcutaneous

Immunogen-

aP
acellular pertussis
ap
acellular pertussis (reduced)
BCG
Bacillus Calmette-Guérin
Chol
cholera
D
diphtheria
d
diphtheria (reduced)
Ecol
enterotoxigenic Escherichia coli
Hib
Haemophilus influenzae type b
HA
hepatitis A
HB
hepatitis B
HPV
human papillomavirus
Inf
influenza
IPV
inactivated poliomyelitis
JE
Japanese encephalitis
Men
meningococcus
Men B
 Neisseria meningitidis Serogroup B protein
 
Meas
measles
Mumps
 mumps
Pneu
pneumococcus
Rab
rabies
Rot
rotavirus
R
rubella
T
tetanus
Typh
typhoid
Var
varicella
YF
yellow fever
Zos
herpes zoster

Adjuvant-

Alum
aluminum-containing adjuvant
AS04
3-O-desacyl-4'-monophosphoryl lipid A adsorbed onto aluminum (as hydroxide salt)
MF59
squalene, polysorbate 80, sorbitan trioleate, sodium citrate, citric acid, water for injection

Preservative-

CH2O
formaldehyde
P
phenol
PE
2-phenoxyethanol
Tm:
thimerosal

Products with active drug identification numbers (DIN):

The following vaccines are authorized for marketing in Canada but are not generally available:

  • Epaxal® (Berna Biotech Ltd.)
  • Liquid Pedvax HIB® (Merck Canada Inc.)
  • Pentacel® (Sanofi Pasteur Ltd.)
  • Prevnar® (Pfizer Canada Inc.)
  • Vivotif® L (Berna Biotech Ltd.)
  • Zostavax® II (Merck Canada Inc.)

Table 2: Types and Contents of Passive Immunizing Agents Available for Use in Canada

  • For current, complete prescribing information vaccine providers should consult the product leaflet or information contained within the product monograph available through Health Canada's Drug Product Database.
  • Information about the passive immunizing agent manufacturer/distributor is available in Passive Immunizing Agents in Part 5.
Table 2: Types and Contents of Passive Immunizing Agents Available for Use in Canada
Brand name Route Passive immunizing
agent type
Protects against or treats Preservative Potential allergens Other materials Abbreviation
ANTIDIPHTHERIA SERUM IV Antitoxin D P Equine protein Sodium chloride DAtx
Cytogam® IV Immune globulin CMV     Sucrose
Human albumin
CMVIg
GamaSTAN® S/D IM Immune globulin HA
Meas
    Glycine
Human plasma protein
Sodium chloride
Water for injection
Ig
HepaGam B® IM Immune globulin HB     Human plasma protein
Maltose
Polysorbate 80
Tri-n-butyl phosphate
Triton® X-100
HBIg
HyperHEP B® S/D IM Immune globulin HB     Glycine
Human plasma protein
Sodium chloride
Water for injection
HBIg
HYPERRAB™ S/D IM/ -local Immune globulin Rab     Glycine
Human plasma protein
Sodium chloride
Water for injection
RabIg
HYPERTET® S/D IM Immune globulin Tet     Glycine
Human plasma protein
Sodium chloride
Water for injection
TIg
IMOGAM® Rabies Pasteurized IM/ -local Immune globulin Rab   Latex in vial stopper Glycine
Human plasma protein
Hydrochloric acid
Sodium hydroxide
Sodium chloride
RabIg
SYNAGIS® (palivizumab) IM Humanized monoclonal antibody RSV     Glycine
Histidine
Mannitol
Water for injection
RSVAb
CNJ-016™ IV Immune globulin Vaccinia     Maltose
Polysorbate 80
Water for injection
VIG
VariZIGTM IV/ IM Immune globulin Var     Glycine
Human plasma protein
Polysorbate 80
Sodium chloride
Sodium phosphate
Tri-n-butyl phosphate
Triton® X-100
VarIg
  • Empty boxes indicate that there are no materials of relevance in the product.

Abbreviations:

Route-

IM
intramuscular
IV
intravenous

Protects against or treats-

D
diphtheria
HA
hepatitis A
HB
hepatitis B
Meas
measles
R
rubella
Rab:
rabies
RSV
respiratory syncytial virus
T
tetanus
Var
varicella

Preservative-

P
phenol

Products with active drug identification numbers (DIN):

The following passive immunizing agent is authorized in Canada but is not generally available:

  • Immune Serum Globulin (Human) (Grifols Therapeutics Inc.)

Selected References

  • Keith LS, Jones DE, Chou C. Aluminum toxicokinetics regarding infant diet and vaccinations. Vaccine 2002;20:S13-17.
  • Offit PA, Jew RK. Addressing parents' concerns: Do vaccines contain harmful preservatives, adjuvants, additives, or residuals? Pediatrics 2003;112:1394-97.

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