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TABLE 3
Length of chemical substance exposure and risk of bladder cancer in males, 1994-1997

Exposure to chemicals (years)*

No. of cases

No. of controls

 

n = 549

%

n = 1,099

%

OR (95% CI)†

p value for trend

Asbestos

 

Never exposed

462

84.2

971

88.4

1.0

0.20

 

1-9

42

7.7

57

5.2

1.7 (1.1-2.6)

 

 

10-19

16

2.9

26

2.4

1.1 (0.6-2.2)

 

 

>20

19

3.5

28

2.6

1.4 (0.7-2.7)

 

Coal tar, soot, pitch, creosote, asphalt

 

Never exposed

445

81.1

928

84.4

1.0

0.43

 

1-9

54

9.8

87

7.9

1.3 (0.9-1.9)

 

 

10-19

13

2.4

27

2.5

0.8 (0.4-1.6)

 

 

>20

20

3.6

26

2.4

1.2 (0.6-2.3)

 

Mineral, cutting or lubricating oil

 

Never exposed

400

72.9

873

79.4

1.0

0.02

 

1-9

42

7.7

68

6.2

1.6 (1.0-2.5)

 

 

10-19

29

5.3

49

4.5

1.4 (0.8-2.3)

 

 

>20

54

9.8

81

7.4

1.3 (0.9-1.9)

 

Benzidine

 

Never exposed

535

97.5

1,083

98.5

1.0

0.26

 

1-9

6

1.1

4

0.4

2.7 (0.7-10.5)

 

 

10-19

0

0.0

3

0.3

 

 

 

>20

5

0.9

5

0.5

2.7 (0.7-9.1)

 

Dyestuffs

 

Never exposed

526

95.8

1,075

97.8

1.0

< 0.01

 

1-9

7

1.3

15

1.4

1.1 (0.4-2.8)

 

 

10-19

4

0.7

2

0.2

3.4 (0.6-20.9)

 

 

>20

6

1.1

3

0.3

4.7 (0.9-23.8)

 

Mustard gas

 

Never exposed

541

98.5

1,093

99.5

1.0

 

 

1-9

2

0.4

4

0.4

0.8 (0.1-5.1)

 

 

10-19

0

0.0

0

0.0

 

 

 

>20

0

0.0

0

0.0

 

 

Welding materials

 

Never exposed

383

69.8

835

76.0

1.0

0.21

 

1-9

45

8.2

101

9.2

1.1 (0.7-1.6)

 

 

10-19

52

9.5

80

7.3

1.3 (0.9-1.9)

 

 

>20

0

0.0

0

0.0

 

 

Arsenic salts

 

Never exposed

541

98.5

1,085

98.7

1.0

0.16

 

1-9

2

0.4

10

0.9

0.9 (0.2-4.3)

 

 

10-19

1

0.2

2

0.2

1.2 (0.1-14.1)

 

 

>20

4

0.7

3

0.1

6.6 (0.6-68.9)

 

Chromium salts

 

Never exposed

541

98.5

1,078

98.1

1.0

0.58

 

1-9

4

0.7

9

0.8

1.0 (0.2-3.6)

 

 

10-19

1

0.2

8

0.7

0.2 (0.0-1.8)

 

 

>20

2

0.4

1

0.1

3.2 (0.2-41.0)

 

Cadmium salts

 

Never exposed

541

98.5

1,084

98.6

1.0

0.20

 

1-9

0

0.0

8

0.7

 

 

 

10-19

2

0.4

4

0.4

0.8 (0.1-4.4)

 

 

>20

3

0.6

1

0.1

6.8 (0.7-71.7)

 

Isopropyl oil

 

Never exposed

531

96.7

1,079

98.2

1.0

0.14

 

1-9

6

1.1

9

0.8

1.3 (0.4-3.9)

 

 

10-19

4

0.7

6

0.6

1.1 (0.3-4.1)

 

 

>20

4

0.7

4

0.4

1.6 (0.4-6.7)

 

Vinyl chloride

 

Never exposed

533

97.1

1,072

97.5

1.0

0.58

 

1-9

8

1.5

16

1.5

0.9 (0.3-2.4)

 

 

10-19

3

0.6

4

0.4

1.4 (0.3-6.7)

 

 

>20

2

0.4

5

0.5

0.6 (0.1-3.3)

 

Pesticides

 

Never exposed

434

79.1

898

81.7

1.0

0.21

 

1-9

29

5.3

40

3.6

1.5 (0.9-2.5)

 

 

10-19

9

1.6

25

2.3

0.8 (0.3-1.7)

 

 

>20

22

4.0

47

4.3

0.9 (0.5-1.6)

 

Herbicides

 

Never exposed

451

82.2

910

82.8

1.0

0.98

 

1-9

22

4.0

37

3.4

1.2 (0.7-2.2)

 

 

10-19

8

1.5

21

1.9

0.9 (0.4-2.1)

 

 

>20

27

4.9

47

4.3

1.1 (0.6-1.9)

 

Radiation sources

 

Never exposed

509

92.7

1,021

92.9

1.0

0.98

 

1-9

20

3.6

34

3.1

1.4 (0.7-2.5)

 

 

10-19

7

1.3

12

1.1

0.9 (0.3-2.6)

 

 

>20

7

1.3

26

2.4

0.5 (0.2-1.3)

 

Wood dust

 

Never exposed

365

66.5

740

67.3

1.0

0.13

 

1-9

45

8.2

119

10.8

0.8 (0.6-1.2)

 

 

10-19

20

3.6

53

4.8

0.8 (0.4-1.4)

 

 

>20

44

8.0

75

6.8

1.2 (0.8-1.8)

 

*Ever exposed for more than one year.
† Adjusted for province, age, pack years of smoking, education, exposure years, coffee and tea consumption.