Home > Infectious Diseases > Canada Communicable Disease Report (CCDR) > 2014 Volume 40 > CCDR: Volume 40-18, November 20, 2014 > Text Equivalents
| Type of transfusion-related adverse reaction | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 |
|---|---|---|---|---|---|---|---|
| Transfusion-associated circulatory overload | 15 | 12.7 | 14.5 | 12.5 | 16.7 | 18.2 | 16.6 |
| Acute hemolytic reaction | 2 | 0.6 | 1.7 | 1.2 | 1.4 | 1.3 | 1.2 |
| Severe allergic reaction | 5.2 | 4.4 | 4.8 | 4.4 | 7.1 | 4.2 | 5.2 |
| Hypotensive reaction | 4 | 3.5 | 3.9 | 3 | 3.6 | 2.5 | 4.9 |
| Delayed hemolytic reaction | 1.6 | 1.3 | 2.9 | 3.3 | 2.8 | 3.1 | 3 |
| Transfusion-related acute lung injury | 1.7 | 1.4 | 0.6 | 0.8 | 0.7 | 1 | 0.6 |
| Possible Transfusion-related acute lung injury | 0.4 | 0.1 | 1.2 | 0.8 | 1.2 | 0.7 | 1 |
| Transfusion-associated dyspnea | 1.4 | 0.6 | 1.9 | 1.4 | 3.2 | 1.5 | 1.6 |
| Incompatible transfusion | 0.3 | 0.4 | 1 | 0.6 | 0.5 | 0.7 | 0.8 |
| Bacterial infection | 0.3 | 0.2 | 0.4 | 0.4 | 0.6 | 0.8 | 0.2 |
| Other | 3.6 | 2.7 | 1.5 | 0.6 | 1.9 | 3.3 | 2.9 |
| Unusual reactions | 1.8 | 0.8 | 1 | 0.8 | 1.2 | 0.7 | 2 |
| Life-threatening adverse transfusion reactions, TTISS 2006 – 2012 | Number of reported adverse transfusion reactions |
|---|---|
| Transfusion-associated circulatory overload (35%) | 94 |
| Acute hemolytic reaction (5%) | 14 |
| Severe allergic/anaphylactic/ anaphylactoid reaction (15%) | 39 |
| Hypotensive reaction (6%) | 17 |
| Delayed hemolytic reaction (2%) | 5 |
| Transfusion-related acute lung injury (12%) | 32 |
| Possible Transfusion-related acute lung injury (9%) | 23 |
| Transfusion-associated dyspnea (4%) | 11 |
| Aseptic meningitis (0%) | 1 |
| Incompatible transfusion (1%) | 3 |
| Bacterial infection (2%) | 5 |
| Other (7%) | 20 |
| Unusual reactions (2%) | 6 |
Return to Figure 2: Life-threatening adverse transfusion reactions, TTISS 2006 – 2012
| Severe adverse transfusion reactions, TTISS 2006 – 2012 | Number of reported adverse transfusion reactions |
|---|---|
| Transfusion-associated circulatory overload (36%) | 565 |
| Acute hemolytic reaction (5%) | 83 |
| Severe allergic/anaphylactic/ anaphylactoid reaction (21%) | 332 |
| Hypotensive reaction (6%) | 98 |
| Delayed hemolytic reaction (8%) | 116 |
| Transfusion-related acute lung injury (3%) | 41 |
| Possible Transfusion-related acute lung injury (2%) | 36 |
| Transfusion-associated dyspnea (3%) | 53 |
| Intravenous immunoglobulin (IVIG) Headache (2%) | 34 |
| Aseptic meningitis (2%) | 27 |
| Incompatible transfusion (1%) | 20 |
| Bacterial infection (1%) | 16 |
| Other (8%) | 117 |
| Unusual reactions (2%) | 26 |
Return to Figure 3: Severe adverse transfusion reactions, TTISS 2006 – 2012
Figure 1 presents a flow diagram of the literature search and study selection process for systematic reviews on rapid HIV testing. The initial search yielded a total of 892 articles. After limiting the search to systematic reviews, 877 articles were removed, resulting in a total of 74 reviews. After title and abstract screening, 62 narratives were removed leaving 12 systematic reviews. Another four studies were excluded; of which, one study had no mention of HIV rapid or POC testing and three studies were diagnostic and/or lab-based. A final number of 8 systematic reviews were included in this rapid review.