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Volume 37 • ACS-7
November 2011

An Advisory Committee Statement (ACS)
National Advisory Committee on Immunization (NACI)

Recommendations on the use of live, attenuated influenza vaccine (FluMist®): Supplemental Statement on Seasonal Influenza Vaccine for 2011-2012


List of Abbreviations

ca
cold-adapted
att
attenuated
CAIV-T
Cold-adapted, influenza vaccine, trivalent (refrigerated formulation)
CCDR
Canada Communicable Disease Report
CCI
Culture-confirmed influenza
CI
Confidence interval
CMI
Cell-mediated immune response
EMEA
European Medicines Evaluation Agency
FFU
Fluorescent focus units
GMT
Geometric mean titre
GMR
Geometric mean ratio
HA
Haemagglutinin antigen
HI
Haemagglutination inhibition
IgG
Immuneglobulin G
IIT
Intent-to-treat
LAIV
Live attenuated influenza vaccine (frozen formulation)
LRTD
Lower respiratory tract disease
mL
Millilitres
MAARI
Medically attended acute respiratory illness
MDV
Master donor virus strain
MSW
Medically significant wheezing
MVS
Master virus seed
NACI
National Advisory Committee on Immunization
pp
per protocol (population evaluated in final analysis)
SAE
Serious adverse event
SPF
Specific pathogen-free
TCID
Tissue-culture infective dose
TIV
Trivalent inactivated influenza vaccine (injectable)
ts
temperature sensitive
µg
Microgram
WHO
World Health Organization

Acknowledgements

† This statement was prepared and approved by NACI.

Members: Dr. J. Langley (Chair), Dr. B. Warshawsky (Vice-Chair), Dr. C. Cooper, Dr. N. Crowcroft, Ms. A. Hanrahan, Dr. B. Henry, Dr. D Kumar, Dr. S. McNeil, Dr. C. Quach-Thanh, Dr. B. Seifert, Dr. D. Skowronski, , Dr. Wendy Vaudry, Dr. Richard Warrington.

Liaison Representatives: Dr. J. Brophy (Canadian Association for Immunization Research and Evaluation), Dr. A. Mawle (U.S. Center for Disease Control and Prevention), Dr. Heather Morrison, (Council of Chief Medical Officers of Health) Ms. S. Pelletier (Community Hospital Infection Control Association), Dr. A. Opavsky (Association of Medical Microbiology and Infectious Disease Canada), Ms. K. Pielak (Canadian Nursing Coalition for Immunization), Dr. P. Plourde (Committee to Advise on Tropical Medicine and Travel), Dr. S. Rechner (College of Family Physicians of Canada), Dr. M. Salvadori (Canadian Paediatric Society), Dr. V. Senikas (Society of Obstetricians and Gynaecologists of Canada), Dr. N. Sicard (Canadian Public Health Association).

Ex-Officio Representatives: Lt.-Col. Dr. J. Anderson (Department of National Defence), Dr. Ezzat Farzad (First Nations and Inuit Health Branch – Office of Community Medicine), Dr. A. Klein (Biologics and Genetic Therapies Directorate), Dr. J. Laroche (Centre for Immunization and Respiratory Infectious Disease), Dr. B. Law (Centre for Immunization and Respiratory Infectious Diseases), Ms. D. Poulin (Centre for Immunization and Respiratory Infectious Diseases), Dr. M. Tepper (Department of National Defence)

Additional Influenza Working Group Members: Dr. P. Van Buynder, Dr. B. Cholin, Dr. G. DeSerres, Dr. I. Gemmill, Dr. S. Halperin.

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