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Table 4. Proposed once daily dosing schedule for amantadine solution (10 mg/mL) in persons age >65 years*
Creatinine clearance |
Initial dose (day 1) |
Subsequent doses (starting day 2) |
80 mL/min or greater |
100mg |
100 mg/day (10 mL) |
60-79 mL/min |
100mg |
75 mg/day (7.5 mL) |
40-59 mL/min |
100mg |
50 mg/day (5 mL) |
20-39 mL/min |
100mg |
25 mg/day (2.5 mL) |
10 à 19 mL/min |
100mg |
‡ |
* |
Table reproduced with permission of McGeer et al(99) and the Canadian Journal of Infectious Diseases. Daily dosing increments set at 2.5 mL to permit the use of medicine cups marked at 2.5 mL. |
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‡ |
No daily dose; if outbreak continues, repeat 100 mg dose every 7 days during the outbreak |
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