Table 5. Total defined daily doses per 1,000 inhabitant-days for all oral antimicrobials dispensed by retail pharmacies in Canada, 2000–2009.
  ATC Class Antimicrobial DDD/1,000 inhabitants-days
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
Roman numerals I to III indicate the ranking of antimicrobials based on importance in human medicine as outlined by the Veterinary Drugs Directorate.
ATC = Anatomical Therapeutic Chemical. DDD = Defined daily dose. NPD = No prescriptions dispensed.
I Combinations of penicillins, including ß-lactamase inhibitors (J01CR) Amoxicillin and enzyme inhibitor (J01CR02) 0.51 0.52 0.50 0.52 0.52 0.59 0.64 0.67 0.71 0.75
Third-generation cephalosporins (J01DD) Cefixime (J01DD08) 0.10 0.09 0.08 0.07 0.06 0.06 0.06 0.06 0.07 0.07
Fluoroquinolones (J01MA) Ofloxacin (J01MA01) 0.13 0.11 0.09 0.08 0.07 0.06 0.06 0.05 0.05 0.04
Ciprofloxacin (J01MA02) 1.14 1.06 1.04 1.07 1.08 1.11 1.20 1.20 1.20 1.20
Norfloxacin (J01MA06) 0.28 0.27 0.26 0.24 0.22 0.21 0.19 0.17 0.15 0.14
Levofloxacine (J01MA12) 0.27 0.36 0.32 0.33 0.32 0.29 0.27 0.25 0.24 0.23
Moxifloxacin (J01MA14) 0.01 0.11 0.19 0.24 0.26 0.32 0.40 0.43 0.42 0.42
Glycopeptides (J01XA) Vancomycin (J01XA01) < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01
Imidazole (J01XD) Metronidazole (J01XD01) NPD 0.21 0.22 0.22 0.22 0.23 0.24 0.23 0.24 0.24
Linezolid (J01XX) Linezolid (J01XX08) NPD < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01
II Penicillins with extended spectrum (J01CA) Ampicilline (J01CA01) 0.06 0.05 0.04 0.04 0.03 0.03 0.02 0.02 0.02 0.02
Amoxicillin (J01CA04) 4.79 4.66 4.43 4.40 4.24 4.42 4.53 4.36 4.39 4.52
Pivampicillin (J01CA02) 0.21 0.19 0.15 0.13 0.11 0.08 0.06 0.05 0.02 < 0.01
ß-lactamase sensitive penicillins (J01CE) Penicillin G (J01CE01) < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01
Penicillin V (J01CE02) 0.67 0.63 0.60 0.60 0.55 0.56 0.62 0.58 0.58 0.56
ß-lactamase resistant penicillins (J01CF) Cloxacillin (J01CF02) 0.37 0.35 0.32 0.31 0.28 0.25 0.24 0.21 0.19 0.18
First-generation cephalosporins (J01DB) Cephalexin (J01DB01) 0.72 0.74 0.78 0.82 0.84 0.89 0.96 0.94 0.94 0.94
Cefadroxil (J01DB05) 0.02 0.03 0.03 0.03 0.03 0.03 0.04 0.04 0.04 0.04
Second-generation cephalosporins (J01DC) Cefaclor (J01DC04) 0.37 0.27 0.19 0.15 0.11 0.09 0.07 0.05 0.04 0.04
Cefprozil (J01DC10) 0.22 0.25 0.29 0.34 0.38 0.39 0.39 0.35 0.34 0.33
Cefuroxime axetil (J01DC02) 0.80 0.69 0.56 0.51 0.46 0.47 0.45 0.43 0.42 0.41
Combinations of sulfonamides and trimethoprim, including derivatives (J01EE) Sulfamethoxazole et trimethoprime (J01EE01) 1.38 1.25 1.12 1.04 0.92 0.84 0.84 0.78 0.77 0.76
Sulfadiazine et trimethoprim (J01EE02) 0.01 0.01 0.01 < 0.01 < 0.01 < 0.01 < 0.01 NPD < 0.01 < 0.01
Macrolides (J01FA) Azithromycin (J01FA10) 0.53 0.65 0.73 0.82 0.76 0.83 0.83 0.78 0.78 0.79
Clarithromycin (J01FA09) 2.22 2.25 2.11 2.23 2.18 2.48 2.64 2.68 2.70 2.79
Erythromycin (J01FA01) 0.88 0.72 0.57 0.52 0.43 0.36 0.33 0.28 0.25 0.21
Lincosamides (J01FF) Clindamycin (J01FF01) 0.24 0.27 0.28 0.31 0.32 0.32 0.36 0.37 0.38 0.39
Aminoglycosides (J01GB) Tobramycin (J01GB01) NPD NPD NPD NPD NPD NPD < 0.01 0.01 0.01 0.01
Other quinolones, excluding fluoroquinolones (J01MB) Nalidixic acid (J01MB02) < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 NPD < 0.01
Sulfonamide combinations, excluding trimethoprim (J01RA) Erythromycin-sulfisoxazole (J01RA02) 0.03 0.02 0.01 0.01 0.01 0.01 < 0.01 < 0.01 < 0.01 < 0.01
Steroid antimicrobials (j01XC) Fusidic acid (J01XC01) < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01
III Tetracyclines (J01AA) Doxycycline (J01AA02) 0.75 0.73 0.70 0.71 0.70 0.74 0.81 0.85 0.91 0.96
Minocycline (J01AA08) 0.97 1.00 1.01 1.04 1.03 1.04 1.07 1.02 1.00 0.99
Tetracycline (J01AA07) 0.99 0.89 0.83 0.75 0.67 0.63 0.60 0.52 0.48 0.46
Amphenicols (J01BA) Chloramphenicol (J01BA01) < 0.01 < 0.01 < 0.01 NPD < 0.01 < 0.01 NPD NPD NPD NPD
Trimethoprim and derivatives (J01EA) Trimethoprim (J01EA01) 0.07 0.07 0.07 0.07 0.06 0.06 0.06 0.05 0.05 0.05
Short-acting sulfonamides (J01EB) Sulfamethizole (J01EB02), sulfapyridine (J01EB04), sulfisoxazole (J01EB05) 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 NPD
Intermediate-acting sulfonamides (J01EC) Sulfadiazine (J01EC02), sulfamethoxazole (J01EC04) < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01
0.01Nitrofuran derivatives (J01XE) Nitrofurantoin (J01XE01) 0.42 0.44 0.45 0.47 0.49 0.52 0.57 0.58 0.61 0.66
Fosfomycin (J01XX) Fosfomycin (J01XX01) < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01
NC Methenamine (J01XX) Methenamine (J01XX05) 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 < 0.01 0.01
  Total (J01)   19.23 18.93 18.11 18.21 17.58 18.13 18.64 18.03 18.00 18.20

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